In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive
transcriptional response sharing a signature of the integrated stress response (ISR) is …

The bile acid–responsive G protein–coupled receptor TGR5 is involved in several metabolic
processes, and recent studies suggest that TGR5 activation may promote pathways that are …

Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory
gene expression by poorly characterized mechanisms. To obtain more insight into the …

Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …

Background & Aims Increased skeletal muscle ammonia uptake with loss of muscle mass
adversely affects clinical outcomes in cirrhosis. Hyperammonemia causes reduced protein …

The endoplasmic reticulum (ER) comprises a network of tubules and vesicles that
constitutes the largest organelle of the eukaryotic cell. Being the location where most …

Dense core vesicles (DCVs) and synaptic vesicles are specialised secretory vesicles in
neurons and neuroendocrine cells, and abnormal release of their cargo is associated with …