Superoxide is a primary oxygen radical that is produced when an oxygen molecule receives
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of
superoxide anion (O 2.-) with unique binding capacity to cell surface and extracellular matrix …

Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal,
and mechanical stress and remains a leading cause of death worldwide. The key …

Coronary heart disease is one of the main causes of death in the developed world, and
treatment success remains modest, with high mortality rates within 1 year after myocardial …

Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates
in patients with cardiometabolic disease. Glucocorticoids are primary stress hormones that …

Gene therapy has revolutionized the field of medicine, offering new hope for those with
common and rare diseases. For nearly three decades, adeno-associated virus (AAV) has …

Introduction: Muscle-directed gene therapy is rapidly gaining attention primarily because
muscle is an easily accessible target tissue and is also associated with various severe …

Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin
mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate …

Under physiological circumstances, there is an exquisite balance between reactive oxygen
species (ROS) production and ROS degradation, resulting in low steady-state ROS levels …

Adeno-associated virus (AAV) has been used to direct gene transfer to a variety of tissues,
including heart, liver, skeletal muscle, brain, kidney and lung, but it has not previously been …