Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …
Temperature-and chemical-induced neurotoxicity in zebrafish
Throughout their lives, humans encounter a plethora of substances capable of inducing
neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests …
neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests …
Common microRNA regulated pathways in Alzheimer's and Parkinson's disease
B Awuson-David, AC Williams, B Wright… - Frontiers in …, 2023 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation. Recently,
miRNA dysregulation has been found in neurodegenerative diseases such as Alzheimer's …
miRNA dysregulation has been found in neurodegenerative diseases such as Alzheimer's …
miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease
SC Chan, CW Tung, CW Lin, YS Tung, PM Wu… - Free Radical Biology …, 2023 - Elsevier
Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
accumulation of mutant Huntingtin protein (mHTT) and oxidative stress-induced neuronal …
accumulation of mutant Huntingtin protein (mHTT) and oxidative stress-induced neuronal …
Therapeutic potential of Coumarin-polyphenolic acid hybrids in PD: Inhibition of α-Syn aggregation and disaggregation of preformed fibrils, leading to reduced …
ZP Wang, W Zhang, LZ Xing, YD Zhao, J Xu… - Bioorganic & Medicinal …, 2024 - Elsevier
This study focuses on the discovery of new potential drugs for treating PD by targeting the
aggregation of α-Syn. A series of hybrids combining Coumarin and phenolic acid were …
aggregation of α-Syn. A series of hybrids combining Coumarin and phenolic acid were …
A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function
Y Wang, J Wang, H Chen, X Li, R Xu, F Gao… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) is the most prevalent neurodegenerative disease
characterized by extracellular senile plaques including amyloid-β peptides and intracellular …
characterized by extracellular senile plaques including amyloid-β peptides and intracellular …
Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington's disease
Huntington's disease (HD) is a paradigm of a genetic neurodegenerative disorder
characterized by the expansion of CAG repeats in the HTT gene. This extensive review …
characterized by the expansion of CAG repeats in the HTT gene. This extensive review …
Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer's Disease: A Critical Review of New and Old Little Regarded Findings
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main
cause of dementia which is characterized by a progressive cognitive decline that severely …
cause of dementia which is characterized by a progressive cognitive decline that severely …
Targeting Mitochondrial Dysfunction and Oxidative Stress to Prevent the Neurodegeneration of Retinal Ganglion Cells
The imbalance of redox homeostasis contributes to neurodegeneration, including that
related to the visual system. Mitochondria, essential in providing energy and responsible for …
related to the visual system. Mitochondria, essential in providing energy and responsible for …
Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that
results in the loss of motor neurons and severe skeletal muscle atrophy. The etiology of ALS …
results in the loss of motor neurons and severe skeletal muscle atrophy. The etiology of ALS …