Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?

C Peggion, T Calì, M Brini - Antioxidants, 2024 - mdpi.com
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …

Temperature-and chemical-induced neurotoxicity in zebrafish

M Toni, C Arena, C Cioni, G Tedeschi - Frontiers in Physiology, 2023 - frontiersin.org
Throughout their lives, humans encounter a plethora of substances capable of inducing
neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests …

Common microRNA regulated pathways in Alzheimer's and Parkinson's disease

B Awuson-David, AC Williams, B Wright… - Frontiers in …, 2023 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation. Recently,
miRNA dysregulation has been found in neurodegenerative diseases such as Alzheimer's …

miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease

SC Chan, CW Tung, CW Lin, YS Tung, PM Wu… - Free Radical Biology …, 2023 - Elsevier
Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
accumulation of mutant Huntingtin protein (mHTT) and oxidative stress-induced neuronal …

Therapeutic potential of Coumarin-polyphenolic acid hybrids in PD: Inhibition of α-Syn aggregation and disaggregation of preformed fibrils, leading to reduced …

ZP Wang, W Zhang, LZ Xing, YD Zhao, J Xu… - Bioorganic & Medicinal …, 2024 - Elsevier
This study focuses on the discovery of new potential drugs for treating PD by targeting the
aggregation of α-Syn. A series of hybrids combining Coumarin and phenolic acid were …

A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function

Y Wang, J Wang, H Chen, X Li, R Xu, F Gao… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) is the most prevalent neurodegenerative disease
characterized by extracellular senile plaques including amyloid-β peptides and intracellular …

Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington's disease

A Shafie, AA Ashour, S Anwar, F Anjum… - Archives of Pharmacal …, 2024 - Springer
Huntington's disease (HD) is a paradigm of a genetic neurodegenerative disorder
characterized by the expansion of CAG repeats in the HTT gene. This extensive review …

Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer's Disease: A Critical Review of New and Old Little Regarded Findings

A Atlante, D Valenti - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main
cause of dementia which is characterized by a progressive cognitive decline that severely …

Targeting Mitochondrial Dysfunction and Oxidative Stress to Prevent the Neurodegeneration of Retinal Ganglion Cells

E Catalani, K Brunetti, S Del Quondam, D Cervia - Antioxidants, 2023 - mdpi.com
The imbalance of redox homeostasis contributes to neurodegeneration, including that
related to the visual system. Mitochondria, essential in providing energy and responsible for …

Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches

GB Kubat, P Picone - Neurological Sciences, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that
results in the loss of motor neurons and severe skeletal muscle atrophy. The etiology of ALS …