The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

The synthesis of nascent RNA is a discontinuous process in which phases of productive
elongation by RNA polymerase are interrupted by frequent pauses. Transcriptional pausing …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

RNA polymerase II contains a repetitive, intrinsically disordered, C-terminal domain (CTD)
composed of heptads of the consensus sequence YSPTSPS. The CTD is heavily …

Our genome is constantly exposed to endogenous and exogenous sources of DNA damage
resulting in various alterations of the genetic code. DNA double-strand breaks (DSBs) are …

Ensuring that one gene's transcription does not inappropriately affect the expression of its
neighbors is a fundamental challenge to gene regulation in a genomic context. In plants …

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a
regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 …

Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated
tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins …

The ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) acts as a non-
canonical cap structure on prokaryotic and eukaryotic ribonucleic acids. Here we find that in …