Antibiotic resistance is one of the most serious challenges that the world is currently facing.
The number of people succumbing to drug-resistant infections is increasing every day, but …

The emergence of antibiotic resistance mechanisms among bacterial pathogens increases
the demand for novel treatment strategies. Lately, the contribution of non-coding RNAs to …

Highlights•SICLOPPS allows the rapid generation of cyclic peptide libraries in cells.•A
variety of cyclic peptide ring sizes may be generated with SICLOPPS.•SICLOPPS libraries …

Notable progress has been made in the therapeutic and research applications of cyclic
peptides since our previous review. New drugs based on cyclic peptides are entering the …

During infection, bacterial pathogens successfully sense, respond and adapt to a myriad of
harsh environments presented by the mammalian host. This exquisite level of adaptation …

Bacteria have evolved several strategies to survive a myriad of harmful conditions in the
environment and in hosts. In Gram-negative bacteria, responses to nutrient limitation …

As key players of gene regulation in many bacteria, small regulatory RNAs (sRNAs)
associated with the RNA chaperone Hfq shape numerous phenotypic traits, including …

Infectious diseases caused by bacterial pathogens still constitute one of the major human
health threats (1). Within the host body, pathogenic bacteria face a wide variety of hostile …

The transport of small molecules across membranes is a pivotal step for controlling the drug
concentration into the bacterial cell and it efficiently contributes to the antibiotic susceptibility …

Antibiotics inhibit a wide range of essential processes in the bacterial cell, including
replication, transcription, translation and cell wall synthesis. In many instances, these …