Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

Hypothermia is a widely used clinical practice for neuroprotection and is a well-established
method to mitigate the adverse effects of some clinical conditions such as reperfusion injury …

Therapeutic hypothermia (TH) has applications dating back millennia. In modern history,
however, TH saw its importation into medical practice where investigations have …

Changes in brain temperature have been reported to affect various brain functions.
However, little is known about the effects of temperature on the neural activity at the network …

Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical
functions, ensures activated brain regions are adequately supplied with oxygen and …

Importance Epilepsy affects at least 1.2% of the population, with one-third of cases
considered to be drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may …

Objective. Local cooling of the brain as a therapeutic intervention is a promising alternative
for patients with epilepsy who do not respond to medication. In vitro and in vivo studies have …

Objective Brain hypothermia controls epileptic discharge and reduces extracellular
concentrations of glutamate (Glu), an excitatory neurotransmitter. We aimed to determine the …

Objective Focal cooling is emerging as a relevant therapy for drug‐resistant epilepsy (DRE).
However, we lack data on its effectiveness in controlling seizures that originate in deep …

This study aimed to understand the mechanism by which brain cooling terminates epileptic
discharge. Cortical slices were prepared from rat brains (n= 19) and samples from patients …