Schizophrenia disorder remains an unsolved puzzle. However, the integration of recent
findings from genetics, molecular biology, neuroimaging, animal models and translational …

Anxiety disorders are currently a major psychiatric and social problem, the mechanisms of
which have been only partially elucidated. The hippocampus serves as a major target of …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Early life stress compromises brain development and can contribute to the development of
mental illnesses. A common animal model used to study different facets of psychiatric …

The extracellular space is occupied by a complex network of proteins creating a mesh-like
assembly known as the extracellular matrix (ECM). ECM assembles into dense net-like …

Depression is an increasingly common but extremely serve mood disorder that remains
poorly understood and inadequately treated. Fast-spiking parvalbumin-positive interneurons …

Chronic stress has an important impact on the adult brain. However, most of the knowledge
on its effects is focused on principal neurons and less on inhibitory neurons. Consequently …

Fluoxetine (Flx) is the most commonly used antidepressant to treat major depressive
disorder. However, its molecular mechanisms of action are not defined as yet. A comparative …