Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma
AH Shah, SR Rivas, TT Doucet-O'Hare… - The Journal of …, 2023 - Am Soc Clin Investig
Human endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8%
of the human genome. Although normally silenced, the most recently integrated provirus …
of the human genome. Although normally silenced, the most recently integrated provirus …
CAR-based immunotherapy of solid tumours—a survey of the emerging targets
J Maher, DM Davies - Cancers, 2023 - mdpi.com
Simple Summary A rapidly emerging new approach to treat cancer involves collection of
patient immune white blood cells and genetic re-programming of the cells to express a new …
patient immune white blood cells and genetic re-programming of the cells to express a new …
Intrinsic signalling factors associated with cancer cell-cell fusion
T Dittmar, R Hass - Cell Communication and Signaling, 2023 - Springer
Cellular fusion eg between cancer cells and normal cells represents a stepwise process that
is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer …
is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer …
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for …
ET Baldwin, M Götte, EP Tchesnokov… - Proceedings of the …, 2022 - National Acad Sciences
Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and
are derived from ancient integrations of retroviruses into the germline. The biology of HERVs …
are derived from ancient integrations of retroviruses into the germline. The biology of HERVs …
Expression of human endogenous retrovirus group K (HERV-K) HML-2 correlates with immune activation of macrophages and type I interferon response
E Russ, N Mikhalkevich, S Iordanskiy - Microbiology Spectrum, 2023 - Am Soc Microbiol
Human endogenous retroviruses (HERVs) comprise about 8.3% of the human genome and
are capable of producing RNA molecules that can be sensed by pattern recognition …
are capable of producing RNA molecules that can be sensed by pattern recognition …
The potential role of human endogenous retrovirus K in glioblastoma
P Hothi, C Cobbs - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
The most active human endogenous retrovirus K (HERV-K) subtype, HML-2, has been
implicated as a driver of oncogenesis in several cancers. However, the presence and …
implicated as a driver of oncogenesis in several cancers. However, the presence and …
The role of HERV-K in cancer stemness
Human endogenous retrovirus-K (HERV-K) is the most recently integrated retrovirus in the
human genome, with implications for multiple disorders, including cancer. Although typically …
human genome, with implications for multiple disorders, including cancer. Although typically …
Human endogenous retroviruses: our genomic fossils and companions
RA Stein, RV DePaola - Physiological Genomics, 2023 - journals.physiology.org
Approximately 8% of the human genome, over four times more than its protein-coding
regions, comprises sequences of viral origin that are known as human endogenous …
regions, comprises sequences of viral origin that are known as human endogenous …
Molecular architecture and conservation of an immature human endogenous retrovirus
The human endogenous retrovirus K (HERV-K) is the most recently acquired endogenous
retrovirus in the human genome and is activated and expressed in many cancers and …
retrovirus in the human genome and is activated and expressed in many cancers and …
Neuromuscular complications of SARS-CoV-2 and other viral infections
S Jacob, R Kapadia, T Soule, H Luo… - Frontiers in …, 2022 - frontiersin.org
In this article we review complications to the peripheral nervous system that occur as a
consequence of viral infections, with a special focus on complications of severe acute …
consequence of viral infections, with a special focus on complications of severe acute …