Allergic rhinitis (AR) is a common disorder affecting up to 40% of the population worldwide
and it usually persists throughout life. Nasal epithelial barrier constitutes the first line of …

Chronic rhinosinusitis (CRS) is a pathological condition characterized by persistent
inflammation in the upper respiratory tract and paranasal sinuses. The epithelium serves as …

Airborne fungi are ubiquitous in the environment and are commonly associated with airway
inflammatory diseases. The innate immune defense system eliminates most inhaled fungi …

Allergic rhinitis (AR) is a common disease affecting 400 million of the population worldwide.
Nasal epithelial cells form a barrier against the invasion of environmental pathogens. These …

Chronic rhinosinusitis (CRS) is a diverse chronic inflammatory disease of the sinonasal
mucosa. CRS manifests itself in a variety of clinical and immunologic patterns. The …

Tight junction (TJ) proteins establish a physical barrier between epithelial cells, playing a
crucial role in maintaining tissue homeostasis by safeguarding host tissues against …

Background Studies have independently indicated that eosinophils and histone
deacetylases (HDACs) may compromise the integrity of the epithelial barrier in nasal polyps; …

Allergic airway disease (AAD) is a collective term for respiratory disorders that can be
exacerbated upon exposure to airborne allergens. The contribution of fungal allergens to …

An impaired epithelial barrier is often observed in allergic rhinitis (AR), which facilitates the
infiltration of allergens. The aim of this study was to investigate the role of autophagy in the …

Chronic rhinosinusitis (CRS) is characterized by inflammatory cell infiltration in the sinonasal
mucosa. Eosinophil and neutrophil extracellular traps (EETs and NETs, respectively) are …