Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells
(OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS) …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function.
Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly
2 decades ago through the identification of rare subpopulations of engrafting cells in …

Studies of the identity and physiological function of mesenchymal stromal cells (MSCs) have
been hampered by a lack of markers that permit both prospective identification and fate …