Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

E Kole, K Jadhav, N Shirsath, P Dudhe… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …

Combined microfluidics and drying processes for the continuous production of micro-/nanoparticles for drug delivery: a review

A Patil, P Patil, S Pardeshi, P Shrimal, N Rebello… - Drying …, 2023 - Taylor & Francis
Drug nanonization and encapsulation efficiency enhancement are prerequisites for
hydrophobic and hydrophilic drugs to be delivered at the targeted site. Microfluidic …

Process development and quality attributes for the freeze-drying process in pharmaceuticals, biopharmaceuticals and nanomedicine delivery: a state-of-the-art review

SR Pardeshi, NS Deshmukh, DR Telange… - Future Journal of …, 2023 - Springer
Background Process intensification is a major hurdle in pharmaceutical process scale-up.
Solvent removal strategies have limited the effectiveness of the overall stability of …

Novel crosslinked nanoparticles of chitosan oligosaccharide and dextran sulfate for ocular administration of dorzolamide against glaucoma

SR Pardeshi, MP More, CV Pardeshi… - Journal of Drug Delivery …, 2023 - Elsevier
Glaucoma is related to the damaged optic nerve leading to the development of high
intraocular pressure. Currently, 12 million people in India suffer from glaucoma, making it the …

[HTML][HTML] Advanced pulmonary drug delivery formulations for the treatment of cystic fibrosis

A Parihar, BG Prajapati, H Paliwal, M Shukla… - Drug Discovery …, 2023 - Elsevier
Cystic fibrosis (CF), a fatal genetic condition, causes thick, sticky mucus. It also causes
pancreatic dysfunction, bacterial infection, and increased salt loss. Currently available …

Development, QbD-based optimisation, in-vivo pharmacokinetics, and ex-vivo evaluation of Eudragit® RS 100 loaded flurbiprofen nanoparticles for oral drug …

S Mandpe, E Kole, V Parate, A Chatterjee… - Journal of …, 2024 - Taylor & Francis
This study aims to develop and evaluate flurbiprofen-loaded polymeric nanoparticles to
achieve sustained drug release, enhancing therapeutic efficacy and minimising dosing …

Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity

E Kole, K Jadhav, Z Khan, RK Verma… - Future Journal of …, 2024 - Springer
Background Vildagliptin (VLG), an antidiabetic agent, presents a potential solution to this
widespread affliction. It exhibits notable attributes, such as a high solubility and a shorter …

Nanomedicines via the pulmonary route: a promising strategy to reach the target?

M Guérin, E Lepeltier - Drug Delivery and Translational Research, 2024 - Springer
Over the past decades, research on nanomedicines as innovative tools in combating
complex pathologies has increased tenfold, spanning fields from infectiology and …

Dry Powder Inhalation for Lung Delivery in Cystic Fibrosis

X Han, D Li, F Reyes-Ortega, EK Schneider-Futschik - Pharmaceutics, 2023 - mdpi.com
Pulmonary drug delivery has long been used for local and systemic administration of
different medications used in acute and chronic respiratory diseases. Certain lung diseases …

Inhalation dosage forms: a focus on dry powder inhalers and their advancements

S Magramane, K Vlahović, P Gordon, N Kállai-Szabó… - Pharmaceuticals, 2023 - mdpi.com
In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on
their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary …