Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

The keratinocyte (KC) is the main functional and structural component of the epidermis, the
most external layer of the skin that is highly specialized in defense against external agents …

Background Our knowledge of etiopathogenesis of atopic dermatitis (AD) is largely derived
from skin biopsies, which are associated with pain, scarring and infection. In contrast, tape …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Background Keratitis ichthyosis deafness (KID) syndrome is a rare disorder caused by
hemichannel (HC) activating gain-of-function mutations in the GJB2 gene encoding …

Epidermal keratinocytes are enriched with at least nine connexins that are key regulators of
epidermal homeostasis. The role of Cx30. 3 in keratinocytes and epidermal health became …

Erythrokeratodermia variabilis et progressiva (EKVP) is a rare hereditary skin disorder
characterized by hyperkeratotic plaques and erythematous patches that progressively …

Connexins are channel-forming proteins that function to facilitate gap junctional intercellular
communication. Here, we use dual cell voltage clamp and dye transfer studies to …

Although inherited GJA1 (encoding Cx43) gene mutations most often lead to
oculodentodigital dysplasia and related disorders, four variants have been linked to …

Connexins are essential for intercellular communication through gap junctions and the
maintenance of cellular and tissue homeostasis. Connexin 43 (Cx43) is the most …