One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Nucleoli form around tandem arrays of a ribosomal gene repeat, termed nucleolar organizer
regions (NORs). During metaphase, active NORs adopt a characteristic undercondensed …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Chromatin instability and mitochondrial decline are conserved processes that contribute to
cellular aging. Although both processes have been explored individually in the context of …

Although a budding yeast culture can be propagated eternally, individual yeast cells age
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …

The structure of the human ribosomal DNA (rDNA) cluster has traditionally been hard to
analyze owing to its highly repetitive nature. However, the recent development of long-read …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

The complex processes and interactions that regulate aging and determine lifespan are not
fully defined for any organism. Here, taking advantage of recent technological advances in …