Obesity, adipose tissue and vascular dysfunction
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …
are strongly associated with comorbidities such as hypertension and insulin resistance …
The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
Control of brown and beige fat development
W Wang, P Seale - Nature reviews Molecular cell biology, 2016 - nature.com
Brown and beige adipocytes expend chemical energy to produce heat and are therefore
important in regulating body temperature and body weight. Brown adipocytes develop in …
important in regulating body temperature and body weight. Brown adipocytes develop in …
Brown and beige fat: physiological roles beyond heat generation
S Kajimura, BM Spiegelman, P Seale - Cell metabolism, 2015 - cell.com
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …
What we talk about when we talk about fat
ED Rosen, BM Spiegelman - Cell, 2014 - cell.com
There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …
Adipogenesis: a complex interplay of multiple molecular determinants and pathways
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale - Nature medicine, 2013 - nature.com
Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …
Adipose tissue browning and metabolic health
Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …
[HTML][HTML] Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
Beige fat, which expresses the thermogenic protein UCP1, provides a defense against cold
and obesity. Although a cold environment is the physiologic stimulus for inducing beige fat in …
and obesity. Although a cold environment is the physiologic stimulus for inducing beige fat in …
Adaptive thermogenesis in adipocytes: is beige the new brown?
J Wu, P Cohen, BM Spiegelman - Genes & development, 2013 - genesdev.cshlp.org
One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …