GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
Recent advances in synthesis and medicinal chemistry of benzodiazepines
Benzodiazepines (BZDs) represent a diverse class of bicyclic heterocyclic molecules. In the
last few years, benzodiazepines have emerged as potential therapeutic agents. As a result …
last few years, benzodiazepines have emerged as potential therapeutic agents. As a result …
Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors
NM Saleh, MSA El-Gaby, K El‐Adl… - Bioorganic …, 2020 - Elsevier
Novel series of diazepam bearing sulfonamide moieties 5 af and 7 ac were designed,
synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell …
synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell …
An ultrasound assisted, ionic liquid-molecular iodine synergy driven efficient green synthesis of pyrrolobenzodiazepine-triazole hybrids as potential anticancer agents
Herein, we report an efficient and eco-friendly, ultrasound assisted synthetic strategy for the
construction of diversified pyrrolobenzodiazepine-triazole hybrids, which are potentially …
construction of diversified pyrrolobenzodiazepine-triazole hybrids, which are potentially …
Click reaction inspired synthesis, antimicrobial evaluation and in silico docking of some pyrrole-chalcone linked 1, 2, 3-triazole hybrids
The discovery of small organic molecules as new antimicrobial agents is a promising
strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt …
strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt …
Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
The anti-Alzheimer potential of novel spiroindolin-1, 2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents
In this study, a new series of spiro indolin-1, 2-diazepine were designed, synthesized, and
screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach …
screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach …
Effective microwave-assisted approach to 1, 2, 3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide–alkyne cycloaddition
MO Mazur, OS Zhelavskyi, EM Zviagin… - Beilstein journal of …, 2021 - beilstein-journals.org
A novel catalyst-free synthetic approach to 1, 2, 3-triazolobenzodiazepinones has been
developed and optimized. The Ugi reaction of 2-azidobenzaldehyde, various amines …
developed and optimized. The Ugi reaction of 2-azidobenzaldehyde, various amines …
Growing Impact of Intramolecular Click Chemistry in Organic Synthesis
MK Jaiswal, VK Tiwari - The Chemical Record, 2023 - Wiley Online Library
Click Chemistry, a modular, rapid, and one of the most reliable tool for the regioselective 1,
2, 3‐triazole forming [3+ 2] reaction of organic azide and terimal alkyne is widely explored in …
2, 3‐triazole forming [3+ 2] reaction of organic azide and terimal alkyne is widely explored in …
Multicomponent Click Reaction: An Indispensable Tool for Easy Access of Functionalized 1, 2, 3‐Triazoles
Multicomponent reactions are operationally simple and display a significant role in diverse
chemical modification by reducing reaction times as well as additional steps involved. In this …
chemical modification by reducing reaction times as well as additional steps involved. In this …