Mechanism exploitation of energy homeostasis is urgently required because of the
worldwide prevailing of obesity-related metabolic disorders in human being. Although it is …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …

Signal transducer and activator of transcription 3 (STAT3) is an important and the most
studied transcription factor in the Janus kinase (JAK)/STAT signaling pathway. STAT3 …

Alternative splicing (AS) is a finely regulated mechanism for transcriptome and proteome
diversification in eukaryotic cells. Correct balance between AS isoforms takes part in …

Overexpression of phosphatases of regenerating liver 2 (PRL2), detected in numerous
diverse cancers, is often associated with increased severity and poor patient prognosis …

Simple Summary STAT3, an oncogene, contributes to insensitivity of chemotherapy and
radiotherapy in tumor, reduces the clinical efficacy. Meanwhile, STAT3β, a STAT3 splicing …

MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML).
However, the tumor-suppressing activities of miR-139 and molecular mechanisms of …

Acute myeloid leukemia (AML) is a heterogenous disease characterized by the clonal
expansion of myeloid progenitor cells. Despite recent advancements in the treatment of …

Aberrant Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling
is implicated in the pathogenesis of acute myeloid leukemia (AML), a highly heterogeneous …