The number of microbiome-related studies has notably increased the availability of data on
human microbiome composition and function. These studies provide the essential material …

An ever-growing body of evidence has linked the gut microbiome with both the effectiveness
and the toxicity of cancer therapies. Radiotherapy is an effective way to treat tumors …

Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …

Purpose: The gut microbiome is involved in antitumor immunotherapy and chemotherapy
responses; however, evidence-based research on the role of gut microbiome in predicting …

Our understanding of how the microbiota affects the balance between response to and
failure of cancer treatment by modulating the tumour microenvironment and systemic …

Microbiome data predictive analysis within a machine learning (ML) workflow presents
numerous domain-specific challenges involving preprocessing, feature selection, predictive …

Colorectal cancer (CRC) is a major contributor to cancer-associated morbidity worldwide
and over one-third of CRC is located in the rectum. Neoadjuvant chemoradiotherapy (nCRT) …

Responses to neoadjuvant chemoradiotherapy (nCRT) and therapy-related toxicities in
rectal cancer vary among patients. To provide the individualized therapeutic option for each …

Simple Summary Gut microbiota is emerging as new diagnostic and prognostic marker
and/or therapeutic target to improve the management of cancer. This review aims to …

Objectives Partial or total resistance to preoperative chemoradiotherapy occurs in more than
half of locally advanced rectal cancer patients. Several novel or repurposed drugs have …