Design of a Membrane-Anchored DNAzyme-Based Molecular Machine for Enhanced Cancer Therapy by Customized Cascade Regulation
MS Wu, ZR Zhou, XY Wang, XC Du… - ACS Pharmacology & …, 2024 - ACS Publications
Synthetic DNAzyme-based structures enable dynamic cell regulation. However, engineering
an effective and targeted DNAzyme-based structure to perform customizable multistep …
an effective and targeted DNAzyme-based structure to perform customizable multistep …
[HTML][HTML] Protocol for constructing tumor-targeting ANM-PROTACs for degradation of transcription factors
J Li, C Liang - STAR protocols, 2024 - Elsevier
Summary AS1411-NCL-MDM2-based proteolysis-targeting chimeras (ANM-PROTACs) are
capable of inducing selective degradation of transcription factors (TFs) in tumor cells. Here …
capable of inducing selective degradation of transcription factors (TFs) in tumor cells. Here …
Design of Mdm2 Protac Degraders with a Built-In Tumor-Targeting Ability
Z Wang, S Yue, X Chen, J Li, P Zhu, H Chen… - Available at SSRN … - papers.ssrn.com
MDM2 is a negative regulator of tumor suppressor p53 and serves as a therapeutic target for
various cancers. Currently, there are no clinically available antitumor drugs modulating …
various cancers. Currently, there are no clinically available antitumor drugs modulating …