Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …

The Dystrophin-Associated Protein Complex (DAPC) is a well-defined and evolutionarily
conserved complex in animals. DAPC interacts with the F-actin cytoskeleton via dystrophin …

All primary chemical interactions weaken under mechanical stress, which imposes
fundamental mechanical limits on the materials constructed from them. Biological materials …

α-Catenin couples the cadherin–catenin complex to the actin cytoskeleton. The
mechanosensitive α-Catenin M region undergoes conformational changes upon application …

Force transmission through adherens junctions (AJs) is crucial for multicellular organization,
wound healing and tissue regeneration. Recent studies shed light on the molecular …

Development is a complex process that occurs throughout the life cycle. F-actin, a major
component of the cytoskeleton, is essential for the morphogenesis of tissues and organs …

One of the main goals in T cell biology has been to investigate how TCR recognition of
peptide: MHC (pMHC) determines T cell phenotype and fate. Ag recognition is required to …

Cell signaling is a fundamental cellular process that enables cells to sense and respond to
information in their surroundings. At the molecular level, signaling is primarily carried out by …

Unlike most adhesive bonds, biological catch bonds strengthen with increased tension. This
characteristic is essential to specific receptor-ligand interactions, underpinning biological …

Background Malignant melanoma is a highly heterogeneous skin cancer with the highest
mortality rate among dermatological cancers. Catenins form functional networks in the …