[HTML][HTML] Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

TI Janjua, Y Cao, F Kleitz, M Linden, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They
have been used in many different biomedical fields including diagnosis, biosensing and …

Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

The intracellular fate and transport mechanism of shape, size and rigidity varied nanocarriers for understanding their oral delivery efficiency

X Li, SM Jafari, F Zhou, H Hong, X Jia, X Mei, G Hou… - Biomaterials, 2023 - Elsevier
Nanocarriers have become an effective strategy to overcome epithelial absorption barriers.
During the absorption process, the endocytosis mechanisms, cell internalization pathways …

Nanomaterials: the new antimicrobial magic bullet

J Ndayishimiye, T Kumeria, A Popat… - ACS Infectious …, 2022 - ACS Publications
Bacterial infections are a significant cause of mortality and morbidity worldwide, despite
decades of use of numerous existing antibiotics and constant efforts by researchers to …

Powering mesoporous silica nanoparticles into bioactive nanoplatforms for antibacterial therapies: strategies and challenges

B Li, Y Liao, X Su, S Chen, X Wang, B Shen… - Journal of …, 2023 - Springer
Bacterial infection has been a major threat to worldwide human health, in particular with the
ever-increasing level of antimicrobial resistance. Given the complex microenvironment of …

[HTML][HTML] Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma

TI Janjua, Y Cao, A Ahmed-Cox, A Raza… - Journal of Controlled …, 2023 - Elsevier
The prognosis of brain cancers such as glioblastoma remains poor despite numerous
advancements in the field of neuro-oncology. The presence of the blood brain barrier (BBB) …

[HTML][HTML] Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives

S Asad, AC Jacobsen, A Teleki - Current Opinion in Chemical Engineering, 2022 - Elsevier
Oral delivery is the preferred route of drug administration due to patient compliance and
convenience. Despite this, nanomedicines have so far primarily been developed for the …

[HTML][HTML] Porous silicon embedded in a thermoresponsive hydrogel for intranasal delivery of lipophilic drugs to treat rhinosinusitis

S Bakshi, P Pandey, Y Mohammed, J Wang… - Journal of Controlled …, 2023 - Elsevier
Intranasal delivery is the most preferred route of drug administration for treatment of a range
of nasal conditions including chronic rhinosinusitis (CRS), caused by an infection and …

Nanoparticle-laden contact lens for controlled release of vancomycin with enhanced antibiotic efficacy

WY Tong, WN Tan, MAK Azizi, CR Leong, IH El Azab… - Chemosphere, 2023 - Elsevier
Vancomycin is the last resort antibiotic for the treatment of severe bacterial keratitis. Its
clinical application is limited due to its hydrophilicity and high molecular weight. To …

Mesoporous silica nanoparticles as carrier to overcome bacterial drug resistant barriers

J Zhuang, Y Yu, R Lu - International Journal of Pharmaceutics, 2023 - Elsevier
Antibiotic resistance has become a global threat to health due to abuse of antibiotics. Lots of
existing antibiotics have lost their effect on drug resistant bacteria. Moreover, the discovery …