[HTML][HTML] Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

[HTML][HTML] The multidimensional mechanisms of long noncoding RNA function

FP Marchese, I Raimondi, M Huarte - Genome biology, 2017 - Springer
A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

Loss of super-enhancer-regulated circRNA Nfix induces cardiac regeneration after myocardial infarction in adult mice

S Huang, X Li, H Zheng, X Si, B Li, G Wei, C Li… - Circulation, 2019 - Am Heart Assoc
Background: circRNAs (circular RNAs) are emerging as powerful regulators of cardiac
development and disease, but their roles in cardiac regeneration are still unknown. This …

The novel regulatory role of lnc RNA‐mi RNA‐mRNA axis in cardiovascular diseases

Y Huang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …

From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo

D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

[PDF][PDF] Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis

T Xie, Y Wang, N Deng, G Huang, F Taghavifar… - Cell reports, 2018 - cell.com
Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …

[HTML][HTML] Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

Evolution to the rescue: using comparative genomics to understand long non-coding RNAs

I Ulitsky - Nature Reviews Genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

W Poller, S Dimmeler, S Heymans, T Zeller… - European heart …, 2018 - academic.oup.com
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

Long non-coding RNAs: new players in cell differentiation and development

A Fatica, I Bozzoni - Nature Reviews Genetics, 2014 - nature.com
Genomes of multicellular organisms are characterized by the pervasive expression of
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …