Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

What roles do mesolimbic and neostriatal dopamine systems play in reward? Do they
mediate the hedonic impact of rewarding stimuli? Do they mediate hedonic reward learning …

The effect of various drugs on the extracellular concentration of dopamine in two terminal
dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate …

Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to
addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals …

The theory is advanced that the common denominator of a wide range of addictive
substances is their ability to cause psychomotor activation. This view is related to the theory …

Rationale: Among the various experimental protocols that have been used to measure drug
reward in laboratory animals, conditioned place preference (CPP) has been one of the most …

The molecular and cellular actions of three classes of abused drugs—opiates,
psychostimulants, and ethanol—are reviewed in the context of behavioral studies of drug …

Reviews recent behavioral and neuropharmacological findings, which suggest that opiate
and stimulant drugs act on common neurochemical systems of the brain to generate positive …

Epidemiological and clinical data indicate high comorbidity between depression and drug
dependence that may reflect an attempt to self-medicate with drugs of abuse. The present …

The discovery that the brain contains neurons utilizing dopamine (DA) as their transmitter
has led to studies of the behavioral function of these neurons. Changes in overall level of …