Although a large sample size is useful for the elucidation of what is called 'missing
heritability', which is an unexplained part of a total phenotypic variance in a quantitative trait …

To understand the genetics of type 2 diabetes in people of Japanese ancestry, we
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …

ABSTRACT The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11,
2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The …

The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence
implicates a role for defective calcium reabsorption in the renal proximal tubule. We …

Background: We established a community-based cohort study to assess the long-term
impact of the Great East Japan Earthquake on disaster victims and gene-environment …

Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness
worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 …

Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-
wide association studies (GWASs) of gout have been reported, they included self-reported …

Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a
heritability of~ 45–60%. We present genome-wide association studies in British and …

Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we
investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese …

Gout is a common disease which results from hyperuricemia. We have reported that the
dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) …