Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …

The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control,
immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC …

Aging-induced functional and phenotypic alterations of the vasculature (eg, endothelial
dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It …

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary
tissues, but an understanding of the physiological role of npGH remains rather limited. Pro …

Sleep is important for normal brain and body functioning, and for this, slow-wave sleep
(SWS), the deepest stage of sleep, is assumed to be especially relevant. Previous studies …

The mitochondria are key organelles regulating vital processes in the eukaryote cell. A
decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and …

Abstract aging is an inevitable biological complex process. It involves the gradual loss of
cellular vitality due to accumulative damage to cellular macromolecules by reactive oxygen …

One of the most devastating chronic consequences of traumatic brain injury (TBI) is cognitive
impairment. One of the possible underlying causes is growth hormone deficiency (GHD) …

Growth hormone (GH) and downstream insulin-like growth factor 1 (IGF1) signaling mediate
growth and metabolism. GH deficiency causes short stature or dwarfism, and excess GH …

Reduced inflammation, increased insulin sensitivity, and protection against cancer are
shared between humans and mice with GH/IGF1 deficiency. Beyond hormone levels …