Mitogen-activated protein kinases (MAPKs) are a family of proteins that constitute signaling
pathways involved in processes that control gene expression, cell division, cell survival …

Perturbed action of signal transduction pathways, including the mitogen-activated protein
(MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the …

Metastases account for the majority of prostate cancer (PCa) deaths, and targeting them is a
major goal of systemic therapy. We identified a novel interaction between two kinases …

Obesity-induced diabetes affects> 400 million people worldwide. Uncontrolled lipolysis (free
fatty acid release from adipocytes) can contribute to diabetes and obesity. To identify future …

Mitogen-activated protein kinase (MAPK) pathways are important signal transduction
pathways that control pivotal cellular processes including proliferation, differentiation …

Abstract Heat shock protein 40 (Hsp40) acts as a co-chaperone with Hsp70 to promote
protein folding, protein transport and degradation. The human Hsp40 family contains more …

Classical mammalian mitogen-activated protein kinase (MAPK) pathways consist of a
cascade of three successive phosphorylation events resulting in the phosphorylation of a …

MAPK-activated protein kinase-5 (MK5) is a protein serine/threonine kinase that is activated
by p38 MAPK and the atypical MAPKs ERK3 and ERK4. The physiological function (s) of …

MAP kinase‐activated protein kinases (MKs), protein serine/threonine kinases downstream
of the MAPKs, regulate a number of biological functions. MK5 was initially identified as a …

Background Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in
one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway …