Mitochondrial calcium exchange in physiology and disease
JF Garbincius, JW Elrod - Physiological reviews, 2022 - journals.physiology.org
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …
fundamental biological process that has critical effects on cellular metabolism, signaling …
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
L Yang, H Youngblood, C Wu, Q Zhang - Translational neurodegeneration, 2020 - Springer
Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and
oxidative stress, which are important factors contributing to the development of brain …
oxidative stress, which are important factors contributing to the development of brain …
The mechanism of MICU-dependent gating of the mitochondrial Ca2+ uniporter
Ca 2+ entry into mitochondria is through the mitochondrial calcium uniporter complex (MCU
cx), a Ca 2+-selective channel composed of five subunit types. Two MCU cx subunits (MCU …
cx), a Ca 2+-selective channel composed of five subunit types. Two MCU cx subunits (MCU …
Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi
There is no effective cure for Chagas disease, which is caused by infection with the
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …
[HTML][HTML] Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics
OPA1 and MICU1 are both involved in the regulation of mitochondrial Ca 2+ uptake and the
stabilization of the cristae junction, which separates the inner mitochondrial membrane into …
stabilization of the cristae junction, which separates the inner mitochondrial membrane into …
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi
In contrast to animal cells, the inositol 1, 4, 5-trisphosphate receptor of Trypanosoma cruzi
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
CRISPR/Cas9 gene editing: A new therapeutic approach in the treatment of infection and autoimmunity
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR‐
associated protein9) may be viewed as an adaptive bacterial immune system. When a virus …
associated protein9) may be viewed as an adaptive bacterial immune system. When a virus …
Down the membrane hole: Ion channels in protozoan parasites
V Jimenez, S Mesones - PLoS pathogens, 2022 - journals.plos.org
Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting developing countries, where coinfection with other …
disproportionally affecting developing countries, where coinfection with other …
Gene editing of putative cAMP and Ca2+‐regulated proteins using an efficient cloning‐free CRISPR/Cas9 system in Trypanosoma cruzi
MA Chiurillo, M Ahmed, C González… - Journal of Eukaryotic …, 2023 - Wiley Online Library
Trypanosoma cruzi, the agent of Chagas disease, must adapt to a diversity of environmental
conditions that it faces during its life cycle. The adaptation to these changes is mediated by …
conditions that it faces during its life cycle. The adaptation to these changes is mediated by …
State‐of‐the‐art CRISPR/Cas9 technology for genome editing in trypanosomatids
N Lander, MA Chiurillo - Journal of Eukaryotic Microbiology, 2019 - Wiley Online Library
CRISPR/Cas9 technology has revolutionized biology. This prokaryotic defense system
against foreign DNA has been repurposed for genome editing in a broad range of cell …
against foreign DNA has been repurposed for genome editing in a broad range of cell …