Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

Abstract Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a well-known vanilloid, which
is the main spicy component in chili peppers, showing several biological activities and the …

Background Chili peppers are commonly consumed spices worldwide and capsaicin is the
main source for the spicy flavors, which is reported to have many biological activities …

Autophagy pathways are involved in the pathogenesis of some obesity related health
problems. As obesity is a nutrient sufficiency condition, autophagy process can be altered in …

Obesity and overweight have become serious health problems in the world and are linked to
a variety of metabolic disorders. Phytochemicals with a weight-loss effect have been widely …

Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

Liver cancer (LC) is the most common cause of cancer death in the United States and the
fifth most common globally. The overexpression of nuclear factor E2 related factor 2 (Nrf2) …

Naringenin is a natural flavonoid that is widely distributed in citrus fruits and
pharmacologically demonstrated to licit lipid-lowering activity. However, the clinical …

Sorafenib is one of the options for advanced hepatocellular carcinoma treatment and has
been shown to extend median overall survival. However, sorafenib resistance often …