Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …
However, developing drugs for central nervous system (CNS) disorders remains the most …
Synergistic antioxidant and antibacterial advantages of essential oils for food packaging applications
N Basavegowda, KH Baek - Biomolecules, 2021 - mdpi.com
The development of food-borne and infectious diseases has increased globally at an
anomalous rate and is combined with emerging social and economic problems. This …
anomalous rate and is combined with emerging social and economic problems. This …
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells
Y Sun, N Berleth, W Wu, D Schlütermann… - Cell death & …, 2021 - nature.com
Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant
and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is …
and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is …
Drug independence and the curability of cancer by combination chemotherapy
Combination chemotherapy can cure certain leukemias and lymphomas, but most solid
cancers are only curable at early stages. We review quantitative principles that explain the …
cancers are only curable at early stages. We review quantitative principles that explain the …
[HTML][HTML] Evaluation of synergism in drug combinations and reference models for future orientations in oncology
Current cancer therapy includes a variety of strategies that can comprise only one type of
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …
Antibiotic adjuvants: a versatile approach to combat antibiotic resistance
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines
H ur Rashid, MAU Martines, AP Duarte, J Jorge… - RSC …, 2021 - pubs.rsc.org
Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …
Oil and gas produced water reuse: Opportunities, treatment needs, and challenges
Advances in water treatment technologies paired with potential restrictions on oil and gas
(O&G) produced water disposal could incentivize the beneficial reuse of treated produced …
(O&G) produced water disposal could incentivize the beneficial reuse of treated produced …
The combined effects of occupational exposure to noise and other risk factors− a systematic review
R Golmohammadi, E Darvishi - Noise and Health, 2019 - journals.lww.com
Purpose: Noise-induced health effects exacerbate by many other risk factors. This
systematic review aims at shedding light on the combined effects of co-exposure to …
systematic review aims at shedding light on the combined effects of co-exposure to …
SYNPRED: prediction of drug combination effects in cancer using different synergy metrics and ensemble learning
Background In cancer research, high-throughput screening technologies produce large
amounts of multiomics data from different populations and cell types. However, analysis of …
amounts of multiomics data from different populations and cell types. However, analysis of …