Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

[HTML][HTML] Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders

RF Spaide, CMG Cheung, H Matsumoto, S Kishi… - Progress in retinal and …, 2022 - Elsevier
In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage
at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal …

Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars

ZS Patel, TJ Brunstetter, WJ Tarver, AM Whitmire… - npj …, 2020 - nature.com
NASA's plans for space exploration include a return to the Moon to stay—boots back on the
lunar surface with an orbital outpost. This station will be a launch point for voyages to …

Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome

J Ong, A Tavakkoli, N Zaman, SA Kamran… - npj …, 2022 - nature.com
The neuro-ocular effects of long-duration spaceflight have been termed Spaceflight
Associated Neuro-Ocular Syndrome (SANS) and are a potential challenge for future, human …

Human health during space travel: state-of-the-art review

C Krittanawong, NK Singh, RA Scheuring, E Urquieta… - Cells, 2022 - mdpi.com
The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Artificial intelligence frameworks to detect and investigate the pathophysiology of spaceflight associated neuro-ocular syndrome (SANS)

J Ong, E Waisberg, M Masalkhi, SA Kamran, K Lowry… - Brain Sciences, 2023 - mdpi.com
Spaceflight associated neuro-ocular syndrome (SANS) is a unique phenomenon that has
been observed in astronauts who have undergone long-duration spaceflight (LDSF). The …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II—imaging techniques and clinical applications

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …

A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration

M Roy-O'Reilly, A Mulavara, T Williams - npj Microgravity, 2021 - nature.com
During spaceflight, the central nervous system (CNS) is exposed to a complex array of
environmental stressors. However, the effects of long-duration spaceflight on the CNS and …

Biomonitoring and precision health in deep space supported by artificial intelligence

RT Scott, LM Sanders, EL Antonsen… - Nature Machine …, 2023 - nature.com
Human exploration of deep space will involve missions of substantial distance and duration.
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …