Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

Biochemical factors can help reprogram somatic cells into pluripotent stem cells, yet the role
of biophysical factors during reprogramming is unknown. Here, we show that biophysical …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

Physical factors in the local cellular microenvironment, including cell shape and geometry,
matrix mechanics, external mechanical forces, and nanotopographical features of the …

Inflammation, following injury, induces cellular plasticity as an inherent component of
physiological tissue repair. The dominant fate of wound macrophages is unclear and …

Maintaining undifferentiated mouse embryonic stem cell (mESC) culture has been a major
challenge as mESCs cultured in Leukemia Inhibitory Factor (LIF) conditions exhibit …

Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …

The phenotypic expression and function of stem cells are regulated by their integrated
response to variable microenvironmental cues, including growth factors and cytokines …