Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)
Biomedical devices are essential for patient diagnosis and treatment; however, when blood
comes in contact with foreign surfaces or homeostasis is disrupted, complications including …
comes in contact with foreign surfaces or homeostasis is disrupted, complications including …
Long-term nitric oxide release and elevated temperature stability with S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As polymer
EJ Brisbois, H Handa, TC Major, RH Bartlett… - Biomaterials, 2013 - Elsevier
Nitric oxide (NO) is known to be a potent inhibitor of platelet activation and adhesion.
Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5 …
Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5 …
Liquid-infused nitric oxide-releasing (LINORel) silicone for decreased fouling, thrombosis, and infection of medical devices
Recent reports on liquid-infused materials have shown promise in creating ultra-low fouling
surfaces, but are limited in their ability to prevent bacterial proliferation and prevent platelet …
surfaces, but are limited in their ability to prevent bacterial proliferation and prevent platelet …
Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical …
Hypothesis Broad-spectrum antimicrobials are needed to mitigate the complicated nature of
antibiotic-resistant infections. It is imperative to formulate new antimicrobials by combining …
antibiotic-resistant infections. It is imperative to formulate new antimicrobials by combining …
Origin of Long-Term Storage Stability and Nitric Oxide Release Behavior of CarboSil Polymer Doped with S-Nitroso-N-acetyl-d-penicillamine
The prolonged and localized delivery of nitric oxide (NO), a potent antithrombotic and
antimicrobial agent, has many potential biomedical applications. In this work, the origin of …
antimicrobial agent, has many potential biomedical applications. In this work, the origin of …
[HTML][HTML] Development of nitric oxide releasing visible light crosslinked gelatin methacrylate hydrogel for rapid closure of diabetic wounds
Management of non-healing and slow to heal diabetic wounds is a major concern in
healthcare across the world. Numerous techniques have been investigated to solve the …
healthcare across the world. Numerous techniques have been investigated to solve the …
Achieving Long-Term Biocompatible Silicone via Covalently Immobilized S-Nitroso-N-acetylpenicillamine (SNAP) That Exhibits 4 Months of Sustained Nitric Oxide …
Ever since the role of endogenous nitric oxide (NO) in controlling a wide variety of biological
functions was discovered approximately three decades back, multiple NO-releasing …
functions was discovered approximately three decades back, multiple NO-releasing …
Enhanced antibacterial efficacy against antibiotic-resistant bacteria via nitric oxide-releasing ampicillin polymer substrates
The emergence of antibiotic-resistant bacteria poses a pressing threat to global health and
is a leading cause of healthcare-related morbidity and mortality. Herein, we report the …
is a leading cause of healthcare-related morbidity and mortality. Herein, we report the …
Improved hemocompatibility of silicone rubber extracorporeal tubing via solvent swelling-impregnation of S-nitroso-N-acetylpenicillamine (SNAP) and evaluation in …
EJ Brisbois, TC Major, MJ Goudie, RH Bartlett… - Acta biomaterialia, 2016 - Elsevier
Blood-contacting devices, including extracorporeal circulation (ECC) circuits, can suffer from
complications due to platelet activation and thrombus formation. Development of nitric oxide …
complications due to platelet activation and thrombus formation. Development of nitric oxide …
Catalyzed nitric oxide release via Cu nanoparticles leads to an increase in antimicrobial effects and hemocompatibility for short-term extracorporeal circulation
Devices used for extracorporeal circulation are met with two major medical concerns:
thrombosis and infection. A device that allows for anticoagulant-free circulation while …
thrombosis and infection. A device that allows for anticoagulant-free circulation while …