[HTML][HTML] Unraveling plant natural chemical diversity for drug discovery purposes

E Lautie, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …

JL Wolfender, JM Nuzillard, JJJ Van Der Hooft… - Analytical …, 2018 - ACS Publications
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

Molecular modeling of the spectroscopic, structural, and bioactive potential of tetrahydropalmatine: insight from experimental and theoretical approach

W Emori, H Louis, SA Adalikwu… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Tetrahydropalmatine have been experimentally reported to have promising biological
applications, although detailed theoretical investigation on its structural activities regarding …

[HTML][HTML] Effects of apigenin on RBL-2H3, RAW264. 7, and HaCaT cells: anti-allergic, anti-inflammatory, and skin-protective activities

CH Park, SY Min, HW Yu, K Kim, S Kim, HJ Lee… - International Journal of …, 2020 - mdpi.com
Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …

[HTML][HTML] Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

Q Hu, C Qu, X Xiao, W Zhang, Y Jiang, Z Wu, D Song… - Chinese medicine, 2021 - Springer
With the advances in biomedical technologies, natural products have attracted substantial
public attention in the area of drug discovery. Flavonoids are a class of active natural …

Propolis antiviral and immunomodulatory activity: a review and perspectives for COVID-19 treatment

N Ripari, AA Sartori, M da Silva Honorio… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives Viral outbreaks are a frequent concern for humans. A great variety of drugs has
been used to treat viral diseases, which are not always safe and effective and may induce …

Eight key rules for successful data‐dependent acquisition in mass spectrometry‐based metabolomics

E Defossez, J Bourquin, S von Reuss… - Mass Spectrometry …, 2023 - Wiley Online Library
In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …

[HTML][HTML] Informatics and computational methods in natural product drug discovery: a review and perspectives

JD Romano, NP Tatonetti - Frontiers in genetics, 2019 - frontiersin.org
The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically,
economically, and socially—in biomedical research. Advances in informatics and …

[HTML][HTML] Advances in indole-containing alkaloids as potential anticancer agents by regulating autophagy

ML Luo, W Huang, HP Zhu, C Peng, Q Zhao… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of death worldwide, and cancer development is often associated
with disturbances in the autophagy process. Autophagy is a catabolic process involved in …

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: current evidence

XJ Wang, JL Ren, AH Zhang, H Sun… - Mass Spectrometry …, 2019 - Wiley Online Library
Current evidence shows that herbal medicines could be beneficial for the treatment of
various diseases. However, the complexities present in chemical compositions of herbal …