Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

Background Critically ill patients undergo extensive physiological alterations that will have
impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet …

Background There is inconsistency between many guidelines in the recommended dose
reduction of renally cleared antibiotics in patients with impaired renal function. Objectives …

Purpose/Background Although Ethiopia is among the thirty high multi-drug resistant
tuberculosis (MDR-TB) burden countries in the world, comparative therapeutic efficacy of …

Background Acute kidney injury (AKI) is a common complication of sepsis, contributing to an
increased mortality rate. However, some studies have demonstrated that renal function …

Accurate assessment of renal function is of great clinical and scientific importance, as it is an
important pharmacokinetic covariate of pivotal drugs. The iohexol clearance is nearly …

Background Only about 50% of intensive care unit (ICU) patients reach a free trough
concentration above MIC (100% fT> MIC) of beta-lactam antibiotics. Although dose …

Antimicrobial stewardship programs (ASPs) have been shown to be effective and safe,
contributing to reducing and adjusting antimicrobial use in clinical practice. Such programs …

No prospective evidence exists on the pharmacokinetic/pharmacodynamic (PK/PD) target
attainment of ceftazidime in adult patients on general wards. We aimed to investigate …

Los programas de optimización del uso de antimicrobianos (PROA) han demostrado ser
una herramienta eficaz y segura, que disminuye y ajusta el uso de antimicrobianos en la …