Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Introduction The mechanisms that lead to cognitive impairment associated with COVID‐19
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …

Ischemic cardiomyopathy (ICM) is a special type of coronary heart disease or an advanced
stage of the disease, which is related to the pathological mechanism of primary dilated …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Background Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs)
exhibit the potential to repair the injured heart after myocardial infarction (MI) by promoting …

Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

Heart failure (HF) patients often suffer from multiple comorbidities, such as diabetes, atrial
fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Heart failure, the leading cause of mortality and morbidity in the developed world, is
characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated …