Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological
aspects are still being investigated. Recently, it has been hypothesized that AD may be …

Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …

Neurodegenerative diseases are characterized by the progressive functional loss of
neurons in the brain, causing cognitive impairment and motoneuron disability. Although …

The amyloid-β (Aβ) peptide has long been considered to be the driving force behind
Alzheimer's disease (AD). However, clinical trials that have successfully reduced Aβ burden …

Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …

The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

This review focuses on research in epidemiology, neuropathology, molecular biology, and
genetics regarding the hypothesis that pathogens interact with susceptibility genes and are …

Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …

Alzheimer's disease (AD) is a progressive neurodegenerative pathology affecting milions of
people worldwide associated with deposition of senile plaques. While the genetic and …

The accumulation of amyloid‐β (Aβ) peptides is a key histopathological feature of the
Alzheimer's brain. Defective clearance mechanisms result in toxic levels of soluble Aβ40 …