The immunobiology and immunopathology of chlamydial infections

ME Ward - Apmis, 1995 - Wiley Online Library
Chlamydiae are obligate intracellular bacterial pathogens of eukaryotic cells responsible for
a wide variety of important human and animal infections. In humans, chlamydial infections …

A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans

J Wang, Y Zhang, C Lu, L Lei, P Yu… - The Journal of …, 2010 - journals.aai.org
A whole genome scale proteome array consisting of 908 open reading frames encoded in
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …

Characterization of Fifty Putative Inclusion Membrane Proteins Encoded in the Chlamydia trachomatis Genome

Z Li, C Chen, D Chen, Y Wu, Y Zhong… - Infection and …, 2008 - Am Soc Microbiol
Although the Chlamydia trachomatis genome is predicted to encode 50 inclusion membrane
proteins, only 18 have been experimentally localized in the inclusion membrane of C …

Caspase-1 Contributes to Chlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection

W Cheng, P Shivshankar, Z Li, L Chen… - Infection and …, 2008 - Am Soc Microbiol
Chlamydia trachomatis infection induces inflammatory pathologies in the upper genital tract,
potentially leading to ectopic pregnancy and infertility in the affected women. Caspase-1 is …

Mice deficient in MyD88 develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection

L Chen, L Lei, X Chang, Z Li, C Lu, X Zhang… - The Journal of …, 2010 - journals.aai.org
MyD88, a key adaptor molecule required for many innate immunity receptor-activated
signaling pathways, was evaluated in a Chlamydia muridarum urogenital tract infection …

Intracellular Interleukin-1α Mediates Interleukin-8 Production Induced by Chlamydia trachomatis Infection via a Mechanism Independent of Type I Interleukin-1 …

W Cheng, P Shivshankar, Y Zhong, D Chen… - Infection and …, 2008 - Am Soc Microbiol
Chlamydia trachomatis infection induces a wide array of inflammatory cytokines and
chemokines, which may contribute to chlamydia-induced pathologies. However, the precise …

[HTML][HTML] Prospects for a vaccine against Chlamydia genital disease I.—Microbiology and pathogenesis

PM Bavoil, RC Hsia, RG Rank - Bulletin de l'Institut Pasteur, 1996 - Elsevier
Microbiology of Chlamydia: The intracellular life cycle.................................... Properties of the
growing bacterium: the reticulate body: Nutrient and energy acquisition …

A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces …

J Wang, L Chen, F Chen, X Zhang, Y Zhang… - Vaccine, 2009 - Elsevier
Chlamydia trachomatis genome is predicted to encode a type III secretion system consisting
of more than 40 open reading frames (ORFs). To test whether these ORFs are expressed …

[HTML][HTML] Conformational mimicry of a chlamydial neutralization epitope on filamentous phage.

G Zhong, GP Smith, J Berry, RC Brunham - Journal of Biological Chemistry, 1994 - Elsevier
Conformational constraints were imposed on a peptide epitope from Chlamydia trachomatis
to improve its ability to elicit antibodies that cross-react with native antigen. Appropriate …

Protective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced …

C Lu, H Zeng, Z Li, L Lei, IT Yeh, Y Wu, G Zhong - Vaccine, 2012 - Elsevier
To search for optimal immunization conditions for inducing protective immunity against
upper genital tract pathologies caused by chlamydial intravaginal infection, we compared …