Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

JK Gjerstad, SL Lightman, F Spiga - Stress, 2018 - Taylor & Francis
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

Cortisol and major depressive disorder—translating findings from humans to animal models and back

LS Nandam, M Brazel, M Zhou, DJ Jhaveri - Frontiers in psychiatry, 2020 - frontiersin.org
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …

Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications

AS Zannas, T Wiechmann, NC Gassen… - …, 2016 - nature.com
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …

Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model

N Matosin, T Halldorsdottir, EB Binder - Biological psychiatry, 2018 - Elsevier
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …

Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism

AS Zannas, EB Binder - Genes, Brain and Behavior, 2014 - Wiley Online Library
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …

Selective inhibitors of the FK506-binding protein 51 by induced fit

S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …

FKBP ligands—where we are and where to go?

JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …

Hsp90: structure and function

SE Jackson - Molecular chaperones, 2013 - Springer
Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

AS Häusl, LM Brix, J Hartmann, ML Pöhlmann… - Molecular …, 2021 - nature.com
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …

Chronic social defeat stress in female mice leads to sex-specific behavioral and neuroendocrine effects

L van Doeselaar, H Yang, J Bordes, L Brix… - Stress, 2021 - Taylor & Francis
Over the years, it has become increasingly clear that males and females respond differently
towards environmental stressors, highlighting the importance of including both sexes when …