Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
JK Gjerstad, SL Lightman, F Spiga - Stress, 2018 - Taylor & Francis
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Selective inhibitors of the FK506-binding protein 51 by induced fit
S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …
established risk factor for stress-related psychiatric disorders such as major depression …
FKBP ligands—where we are and where to go?
JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
Hsp90: structure and function
SE Jackson - Molecular chaperones, 2013 - Springer
Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …
role in many cellular processes including cell cycle control, cell survival, hormone and other …
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
AS Häusl, LM Brix, J Hartmann, ML Pöhlmann… - Molecular …, 2021 - nature.com
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …
Chronic social defeat stress in female mice leads to sex-specific behavioral and neuroendocrine effects
L van Doeselaar, H Yang, J Bordes, L Brix… - Stress, 2021 - Taylor & Francis
Over the years, it has become increasingly clear that males and females respond differently
towards environmental stressors, highlighting the importance of including both sexes when …
towards environmental stressors, highlighting the importance of including both sexes when …