Regulation mechanisms and maintenance strategies of stemness in mesenchymal stem cells
N Jiang, X Tian, Q Wang, J Hao, J Jiang… - Stem cell reviews and …, 2024 - Springer
Stemness pertains to the intrinsic ability of mesenchymal stem cells (MSCs) to undergo self-
renewal and differentiate into multiple lineages, while simultaneously impeding their …
renewal and differentiate into multiple lineages, while simultaneously impeding their …
Impact of diabetes mellitus on human mesenchymal stromal cell biology and functionality: implications for autologous transplantation
Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and
immunomodulatory properties to restore and repair injured tissues, making them attractive …
immunomodulatory properties to restore and repair injured tissues, making them attractive …
Multi-parameter analysis of biobanked human bone marrow stromal cells shows little influence for donor age and mild comorbidities on phenotypic and functional …
Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are
among the most frequently tested cellular therapeutics for treating degenerative and immune …
among the most frequently tested cellular therapeutics for treating degenerative and immune …
Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical …
G Togliatto, P Dentelli, M Gili, S Gallo… - International journal of …, 2016 - nature.com
Methods: ASCs were recovered from 10 obese (oASCs) and 6 non-obese (nASCs)
participants and characterized. In selected experiments, nASCs and oASCs were cultured …
participants and characterized. In selected experiments, nASCs and oASCs were cultured …
Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells
Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) represent
promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the …
promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the …
MiR-93 controls adiposity via inhibition of Sirt7 and Tbx3
M Cioffi, M Vallespinos-Serrano, SM Trabulo… - Cell reports, 2015 - cell.com
Conquering obesity has become a major socioeconomic challenge. Here, we show that
reduced expression of the miR-25-93-106b cluster, or miR-93 alone, increases fat mass …
reduced expression of the miR-25-93-106b cluster, or miR-93 alone, increases fat mass …
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
Q Zheng, L Banaszak, S Fracci, D Basali… - Endocrine-related …, 2013 - erc.bioscientifica.com
Aurora kinases are serine/threonine kinases that play an essential role in cell division. Their
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …
Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics
FC Cassidy, C Shortiss, CG Murphy, SR Kearns… - International Journal of …, 2020 - mdpi.com
Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in
numerous disease settings involving impaired regeneration because of the crucial role they …
numerous disease settings involving impaired regeneration because of the crucial role they …
Equine metabolic syndrome impairs adipose stem cells osteogenic differentiation by predominance of autophagy over selective mitophagy
K Marycz, K Kornicka, M Marędziak… - Journal of cellular …, 2016 - Wiley Online Library
Adipose‐derived mesenchymal stem cells (ASC) hold great promise in the treatment of
many disorders including musculoskeletal system, cardiovascular and/or endocrine …
many disorders including musculoskeletal system, cardiovascular and/or endocrine …
Immunomodulatory functions of adipose mesenchymal stromal/stem cell derived from donors with type 2 diabetes and obesity on CD4 T cells
M Mahmoud, M Juntunen, A Adnan, L Kummola… - Stem Cells, 2023 - academic.oup.com
For adipose stromal/stem cell (ASCs)-based immunomodulatory therapies, it is important to
study how donor characteristics, such as obesity and type 2 diabetes (T2D), influence ASCs …
study how donor characteristics, such as obesity and type 2 diabetes (T2D), influence ASCs …