Enzymatic one-electron reduction of heterocyclic N-oxides can lead to the intracellular
generation of reactive oxygen species via several different chemical pathways. These …

A multiparameter model of the diffusion, antiproliferative assays IC50 and aerobic and
hypoxic clonogenic assays for a wide range of neutral and radical anion forms of …

We investigate dissociative electron attachment to tirapazamine through a crossed electron–
molecule beam experiment and quantum chemical calculations. After the electron is …

Tirapazamine (3-amino-1, 2, 4-benzotriazine 1, 4-dioxide) is a heterocyclic di-N-oxide that
undergoes enzymatic deoxygenation selectively in the oxygen-poor (hypoxic) cells found in …

The initial steps of the activation of tirapazamine (TPZ, 1, 3-amino-1, 2, 4-benzotriazine 1, 4-
N, N-dioxide) under hypoxic conditions consist of the one-electron reduction of 1 to radical …

The 1, 2, 4-benzotriazine 1, 4-dioxides are an important class of potential anticancer drugs
that selectively kill the low-oxygen (hypoxic) cells found in solid tumors. These compounds …

Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN→ O) exhibit
tumoricidal, antibacterial, and antiprotozoal activities, which are typically attributed to …

Many 1, 2, 4‐benzotriazine 1, 4‐dioxides display the ability to selectively kill the oxygen‐
poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford …

Background: The hypoxic microenvironment plays a crucial role in the malignant
progression of tumor cells. Moreover, AKT, a serine/threonine kinase, is activated by various …

The results are reported of an ab initio study of bromine dioxide BrO2, 1, and of the T-
shaped trans-and cis-dihydroxides 2 and 3 of dihydrogen bromate (HO) 2BrO. The …