The use of genomics is firmly established in clinical practice, resulting in innovations across
a wide range of disciplines such as genetic screening, rare disease diagnosis and …

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only
serves as an energy reservoir, but also actively participates in metabolic homeostasis …

Hundreds of millions of single cells have been analyzed using high-throughput
transcriptomic methods. The cumulative knowledge within these datasets provides an …

To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …

Motivation As the generation of complex single-cell RNA sequencing datasets becomes
more commonplace it is the responsibility of researchers to provide access to these data in a …

As the use of single-cell technologies has grown, so has the need for tools to explore these
large, complicated datasets. The UCSC Cell Browser is a tool that allows scientists to …

Abstract Two-dimensional (2D) embedding methods are crucial for single-cell data
visualization. Popular methods such as t-distributed stochastic neighbor embedding (t-SNE) …

Neural networks such as variational autoencoders (VAE) perform dimensionality reduction
for the visualization and analysis of genomic data, but are limited in their interpretability: it is …

Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …