[HTML][HTML] Bone/cartilage targeted hydrogel: Strategies and applications

H Zhang, S Wu, W Chen, Y Hu, Z Geng, J Su - Bioactive materials, 2023 - Elsevier
The skeletal system is responsible for weight-bearing, organ protection, and movement.
Bone diseases caused by trauma, infection, and aging can seriously affect a patient's quality …

[HTML][HTML] Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications

T Bauleth-Ramos, N El-Sayed, F Fontana, M Lobita… - Materials Today, 2023 - Elsevier
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the
transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical …

Dissolvable polymer microneedles for drug delivery and diagnostics

M Ali, S Namjoshi, HAE Benson, Y Mohammed… - Journal of Controlled …, 2022 - Elsevier
Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport
a wide selection of active compounds into the skin. To provide an effective therapeutic …

Microneedles: a new frontier in nanomedicine delivery

E Larrañeta, MTC McCrudden, AJ Courtenay… - Pharmaceutical …, 2016 - Springer
This review aims to concisely chart the development of two individual research fields,
namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles …

Dissolving microneedle patches for dermal vaccination

M Leone, J Mönkäre, JA Bouwstra, G Kersten - Pharmaceutical research, 2017 - Springer
The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility
and a dense network of immune cells in the skin. The development of microneedles is …

Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing

M Wang, L Hu, C Xu - Lab on a Chip, 2017 - pubs.rsc.org
Microneedles are an efficient and minimally invasive approach to transdermal drug delivery
and extraction of skin interstitial fluid. Compared to solid microneedles made of silicon …

Microneedles for gene and drug delivery in skin cancer therapy

D Zhi, T Yang, T Zhang, M Yang, S Zhang… - Journal of Controlled …, 2021 - Elsevier
The success of skin cancer treatment is severely limited in the route of administration
because most genes and drugs cannot break through the excellent stratum corneum (SC) …

[HTML][HTML] Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis

P González-Vázquez, E Larrañeta… - Journal of Controlled …, 2017 - Elsevier
Neonatal infections are a leading cause of childhood mortality in low-resource settings.
World Health Organization guidelines for outpatient treatment of possible serious bacterial …

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell …

G Cole, AA Ali, E McErlean, EJ Mulholland, A Short… - Acta Biomaterialia, 2019 - Elsevier
Castrate resistant prostate cancer (CRPC) remains a major challenge for healthcare
professionals. Immunotherapeutic approaches, including DNA vaccination, hold the …

Microneedle-mediated transdermal delivery of bevacizumab

AJ Courtenay, MTC McCrudden… - Molecular …, 2018 - ACS Publications
Bevacizumab is a recombinant humanized monoclonal antibody used clinically as a
combination chemotherapeutic. Antibody therapeutics are usually formulated as parenteral …