[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization

TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

The translocator protein (TSPO) in mitochondrial bioenergetics and immune processes

C Betlazar, RJ Middleton, R Banati, GJ Liu - Cells, 2020 - mdpi.com
The translocator protein (TSPO) is an outer mitochondrial membrane protein that is widely
used as a biomarker of neuroinflammation, being markedly upregulated in activated …

VDAC1 and the TSPO: expression, interactions, and associated functions in health and disease states

V Shoshan-Barmatz, S Pittala, D Mizrachi - International journal of …, 2019 - mdpi.com
The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM),
serves multiple functions and contributes to numerous processes, including cholesterol …

The role of translocator protein TSPO in hallmarks of glioblastoma

LM Ammer, A Vollmann-Zwerenz, V Ruf, CH Wetzel… - Cancers, 2020 - mdpi.com
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …

The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing

P Singh, A Adhikari, D Singh, C Gond, AK Tiwari - ACS omega, 2022 - ACS Publications
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …

TSPO: an evolutionarily conserved protein with elusive functions

F Bonsack, S Sukumari-Ramesh - International journal of molecular …, 2018 - mdpi.com
TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral
tissue binding sites for benzodiazepines, and was formerly called the peripheral …

Microglial pro-inflammatory and anti-inflammatory phenotypes are modulated by translocator protein activation

E Da Pozzo, C Tremolanti, B Costa… - International journal of …, 2019 - mdpi.com
A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation
has been recently proposed. However, little is known about TSPO-activated pathways …

Diagnostic and therapeutic potential of TSPO studies regarding neurodegenerative diseases, psychiatric disorders, alcohol use disorders, traumatic brain injury, and …

J Dimitrova-Shumkovska, L Krstanoski, L Veenman - Cells, 2020 - mdpi.com
Neuroinflammation and cell death are among the common symptoms of many central
nervous system diseases and injuries. Neuroinflammation and programmed cell death of the …

TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction

Y Mahemuti, K Kadeer, R Su, A Abula, Y Aili… - Experimental …, 2023 - Elsevier
Autophagy is considered a double-edged sword, with a role in the regulation of the
pathophysiological processes of the central nervous system (CNS) after cerebral ischemia …

PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

T Berdyyeva, C Xia, N Taylor, Y He, G Chen… - Molecular Imaging and …, 2019 - Springer
Abstract Purpose The P2X7 receptor, an adenosine triphosphate (ATP)-gated
purinoreceptor, has emerged as one of the key players in neuroinflammatory processes …