The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Transposable elements (TEs) contribute to the large amount of repetitive sequences in
mammalian genomes and have been linked to species-specific genome innovations by …
mammalian genomes and have been linked to species-specific genome innovations by …
Rapid evolution and conserved function of the piRNA pathway
SS Parhad, WE Theurkauf - Royal Society Open Biology, 2019 - royalsocietypublishing.org
Transposons are major genome constituents that can mobilize and trigger mutations, DNA
breaks and chromosome rearrangements. Transposon silencing is particularly important in …
breaks and chromosome rearrangements. Transposon silencing is particularly important in …
[HTML][HTML] Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation
PIWI proteins and their guiding Piwi-interacting small RNAs (piRNAs) are crucial for fertility
and transposon defense in the animal germline. In most species, the majority of piRNAs are …
and transposon defense in the animal germline. In most species, the majority of piRNAs are …
The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility
Abstract Pachytene PIWI-interacting RNAs (piRNAs), which comprise> 80% of small RNAs
in the adult mouse testis, have been proposed to bind and regulate target RNAs like …
in the adult mouse testis, have been proposed to bind and regulate target RNAs like …
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs
PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons.
Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are …
Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are …
Small RNA sequencing revealed dysregulated piRNAs in Alzheimer's disease and their probable role in pathogenesis
PIWI-interacting RNAs (piRNAs),∼ 23–36 nucleotide-long small non-coding RNAs, earlier
believed to be germline-specific, have now been identified in somatic cells including neural …
believed to be germline-specific, have now been identified in somatic cells including neural …
Rapid evolution of piRNA clusters in the Drosophila melanogaster ovary
The piRNA pathway is a highly conserved mechanism to repress transposable element (TE)
activity in the animal germline via a specialized class of small RNAs called piwi-interacting …
activity in the animal germline via a specialized class of small RNAs called piwi-interacting …
The birth of piRNAs: how mammalian piRNAs are produced, originated, and evolved
Abstract PIWI-interacting RNAs (piRNAs), small noncoding RNAs 24–35 nucleotides long,
are essential for animal fertility. They play critical roles in a range of functions, including …
are essential for animal fertility. They play critical roles in a range of functions, including …
A review of discovery profiling of PIWI-interacting RNAs and their diverse functions in metazoans
S Huang, K Yoshitake, S Asakawa - International Journal of Molecular …, 2021 - mdpi.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs (sncRNAs) that
perform crucial biological functions in metazoans and defend against transposable elements …
perform crucial biological functions in metazoans and defend against transposable elements …
The absence of core piRNA biogenesis factors does not impact efficient transposon silencing in Drosophila
S Chary, R Hayashi - PLoS Biology, 2023 - journals.plos.org
Organisms require mechanisms to distinguish self and non-self-RNA. This distinction is
crucial to initiate the biogenesis of Piwi-interacting RNAs (piRNAs). In Drosophila ovaries …
crucial to initiate the biogenesis of Piwi-interacting RNAs (piRNAs). In Drosophila ovaries …