Quantitative metabolic fluxes regulated by trans-omic networks
Cells change their metabolism in response to internal and external conditions by regulating
the trans-omic network, which is a global biochemical network with multiple omic layers …
the trans-omic network, which is a global biochemical network with multiple omic layers …
[HTML][HTML] From regulation of cell fate decisions towards patient-specific treatments, insights from mechanistic models of signalling pathways
M Simon, F Konrath, J Wolf - Current Opinion in Systems Biology, 2024 - Elsevier
Highlights•Models serve as tools to explain how signalling pathways affect cell fate
decisions.•Understanding heterogeneity on different scales is relevant for cell fate …
decisions.•Understanding heterogeneity on different scales is relevant for cell fate …
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle
Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …
Kinetic trans-omic analysis reveals key regulatory mechanisms for insulin-regulated glucose metabolism in adipocytes
Insulin regulates glucose metabolism through thousands of regulatory mechanisms;
however, which regulatory mechanisms are keys to control glucose metabolism remains …
however, which regulatory mechanisms are keys to control glucose metabolism remains …
Dynamic 13C flux analysis captures the reorganization of adipocyte glucose metabolism in response to insulin
Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable
isotope tracers presents unique computational challenges. Here, we developed an efficient …
isotope tracers presents unique computational challenges. Here, we developed an efficient …
Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver
Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and
converting glucose into energy sources; however, the underlying mechanisms are unclear …
converting glucose into energy sources; however, the underlying mechanisms are unclear …
Understanding metabolic flux behaviour in whole-cell model output
S Landon, O Chalkley, G Breese, C Grierson… - Frontiers in molecular …, 2021 - frontiersin.org
Whole-cell modelling is a newly expanding field that has many applications in lab
experiment design and predictive drug testing. Although whole-cell model output contains a …
experiment design and predictive drug testing. Although whole-cell model output contains a …
[HTML][HTML] Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism
Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and
metabolites regulate the involved metabolic pathways. Dysregulation of glucose …
metabolites regulate the involved metabolic pathways. Dysregulation of glucose …
Non-Linear Classifiers for Wet-Neuromorphic Computing using Gene Regulatory Neural Network
Abstract The Gene Regulatory Network (GRN) of biological cells governs a number of key
functionalities that enable them to adapt and survive through different environmental …
functionalities that enable them to adapt and survive through different environmental …
Stability Analysis of Non-Linear Classifiers using Gene Regulatory Neural Network for Biological AI
The Gene Regulatory Network (GRN) of biological cells governs a number of key
functionalities that enables them to adapt and survive through different environmental …
functionalities that enables them to adapt and survive through different environmental …