The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

The endocannabinoid (eCB) system is a lipid-based neurotransmitter complex that plays
crucial roles in the neural control of learning and memory. The current model of eCB …

A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons.
These complex inhibitory interconnections largely contribute to the tight modulation of …

Somatostatin-expressing interneurons (SOMIs) in the mouse dentate gyrus (DG) receive
feedforward excitation from granule cell (GC) mossy fiber (MF) synapses and provide …

Cannabis-inspired medical products are garnering increasing attention from the scientific
community, general public, and health policy makers. A plethora of scientific literature …

The paradigm of fear conditioning is largely responsible for our current understanding of
how memories are encoded at the cellular level. Its most fundamental underlying …

PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain
that has attracted attention as a therapeutic target to treat cognitive disorders. Indeed …

Type 1 spinocerebellar ataxia (SCA1) is a progressive neurodegenerative disorder with no
effective treatment to date. Using mice modeling SCA1, it has been demonstrated that a drug …

Background Cannabis is increasingly being legalized and socially accepted around the
world and is often used with alcohol in social settings. We recently showed that in utero …

Neurons generate various spike patterns to execute different functions. Understanding how
these physiological neuronal spike patterns are related to their molecular characteristics is a …