Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Drug induced kidney injury is a frequent adverse event which contributes to morbidity and
increased healthcare utilization. Our current knowledge of drug induced kidney disease is …

Extracorporeal membrane oxygenation (ECMO) is a form of prolonged cardiopulmonary
bypass used to temporarily sustain cardiac and/or respiratory function in critically ill patients …

ABSTRACT A careful management of antimicrobials is essential in the critically ill with acute
kidney injury, especially if renal replacement therapy is required. Acute kidney injury may …

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug‐resistant
Gram‐positive bacteria, especially methicillin‐resistant Staphylococcus aureus. In the last …

Septic shock remains a global health challenge with millions of cases every year, high rates
of mortality and morbidity, impaired quality of life among survivors and relatives, and high …

Abstract Treatment of infectious diseases is becoming increasingly challenging with the
emergence of less-susceptible organisms that are poorly responsive to existing antibiotic …

Increasing evidence suggests that antibiotic dosing in critically ill patients with acute kidney
injury (AKI) often does not achieve pharmacodynamic goals, and the continued high …