Kinases control a diverse set of cellular processes comprising of reversible phosphorylation
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …

Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho),
is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme …

Metabolic rearrangements subsequent to malignant transformation are not well
characterized in endometrial cancer. Identification of altered metabolites could facilitate …

Since the identification of human choline kinase as a protein target against cancer
progression, many compounds have been designed to inhibit its function and reduce the …

A full understanding of the molecular mechanism of action of choline kinase α (ChoKα)
inhibitors at the cell level is essential for developing therapeutic and preventive approaches …

Olive leaf is a byproduct of the olive tree that is rich in phenolic compounds with potential
anticarcinogenic effects against various cancers, including breast cancer. Nevertheless, the …

Choline kinase (CHOK) is a homodimeric enzyme that catalyzes the transfer of a phosphate
group from ATP to choline to produce ADP and phosphocholine (PCho; Figure 1A), the first …

A novel family of compounds derivative of 1, 1′-(((ethane-1, 2-diylbis (oxy)) bis (4, 1-
phenylene)) bis (methylene))-bispyridinium or–bisquinolinium bromide (10a-l) containing a …

Malaria is a life-threatening disease caused by different species of the protozoan parasite
Plasmodium, with P. falciparum being the deadliest. Increasing parasitic resistance to …

Testing a number of N-[omega-(purin-6-yl) aminoalkanoyl] derivatives of 7, 8-difluoro-3, 4-
dihydro-3-methyl-2 H-[1, 4] benzoxazine in a panel of nine tumor cell lines has shown that …