Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …

Atrial fibrillation is very common among the elderly and/or obese. While myocardial fibrosis
is associated with atrial fibrillation, the exact mechanisms within atrial myocytes and …

During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Fibrosis occurs when the synthesis of extracellular matrix outpaces its degradation, and over
time can negatively impact tissue and organ function. In the case of cardiac fibrosis …

In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to
decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to …

The left atrial posterior wall has many embryologic, anatomic, and electrophysiologic
characteristics, that are important for the initiation and maintenance of persistent atrial …

Computational simulations of cardiac electrophysiology provide detailed information on the
depolarization phenomena at different spatial and temporal scales. With the development of …

Fibrosis has been mechanistically linked to arrhythmogenesis in multiple cardiovascular
conditions, including atrial fibrillation (AF). Previous studies have demonstrated that fibrosis …

The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years,
affecting the quality of life of millions of people, increasing mortality and morbidity, and …

Background Atrial cardiomyopathy (atCM) is an emerging prognostic factor in cardiovascular
disease. Fibrotic remodeling, cardiomyocyte hypertrophy, and capillary density are …