The present article describes the state of the art in the rapidly developing field of bone tissue
engineering, where many disciplines, such as material science, mechanical engineering …

Micro and small bioreactors are well described for use in bioprocess development in pre-
production manufacture, using ultra-scale down and microfluidic methodology. However, the …

Perfusion culture of mesenchymal stem cells (MSCs) seeded in biomaterial scaffolds
provides nutrients for cell survival, enhances extracellular matrix deposition, and increases …

We are introducing the FABRICA, a bioprinter-agnostic 3D-printed bioreactor platform
designed for 3D-bioprinted tissue construct culture, perfusion, observation, and analysis …

Natural killer cell‐derived extracellular vesicles (NK‐EVs) have shown promising potential
as biotherapeutics for cancer due to their unique attributes as cytotoxic nanovesicles against …

The three dimensional (3D) cultivation of stem cells in dynamic bioreactor systems is
essential in the context of regenerative medicine. Still, there is a lack of bioreactor systems …

Despite medical achievements, the number of patients with end-stage kidney disease keeps
steadily raising, thereby entailing a high number of surgical and interventional procedures to …

Bone is a dynamic environment where osteocytes, osteoblasts, and mesenchymal
stem/progenitor cells perceive mechanical cues and regulate bone metabolism accordingly …

In regenerative medicine, computer models describing bioreactor processes can assist in
designing optimal process conditions leading to robust and economically viable products. In …

Natural bone tissue features a complex mechanical environment, with cells responding to
diverse mechanical stimuli, including fluid shear stress (FSS) and hydrostatic pressure (HP) …