Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host
defence. Recent studies have implicated these peptides in the clearance of aberrant cells …

Cecropins are small helical secreted peptides with antimicrobial activity that are widely
distributed among insects. Genes encoding Cecropins are strongly induced upon infection …

The fruit fly Drosophila melanogaster combats microbial infection by producing a battery of
effector peptides that are secreted into the haemolymph. Technical difficulties prevented the …

Sex peptide (SP), a seminal fluid protein of Drosophila melanogaster males, has been
described as driving a virgin-to-mated switch in females, through eliciting an array of …

Mosquitoes are prolific vectors of human pathogens, therefore a clear and accurate
understanding of the organization of their antimicrobial defenses is crucial for informing the …

Parasite proliferations within/on the host form the basis of the outcome of all infectious
diseases. However, within-host dynamics are difficult to study in vertebrates, as it requires …

Innate immune priming increases an organism's survival of a second infection after an initial,
non-lethal infection. We used Drosophila melanogaster and an insect-derived strain of …

Cellular and organismal phenotypes are controlled by complex gene regulatory networks.
However, reference maps of gene function are still scarce across different organisms. Here …

The soil-dwelling nematode Caenorhabditis elegans serves as a model system to study
innate immunity against microbial pathogens. C. elegans have been collected from around …

Chronic infections are a heavy burden on healthcare systems worldwide. Persister cells are
thought to be largely responsible for chronic infection due to their tolerance to antimicrobials …